Circumsporozoite protein of Plasmodium berghei: gene cloning and identification of the immunodominant epitopes.
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منابع مشابه
Intraspecies Gene Variation within Putative Epitopes of Immunodominant Protein P48 of Mycoplasma agalactiae
P48 protein of Mycoplasma agalactiae is used to diagnose infection and was identified as potential vaccine candidate. According to the genetic nature of mycoplasma and variable sensitivity in P48-based serological diagnosis tests, intra species variation of P48 nucleotide sequence investigated in 13 field isolates of difference province of Iran along with three vaccine strains. Samples were col...
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Early hepatic stages of Plasmodium berghei: release of circumsporozoite protein and host cellular inflammatory response.
After injection of Plasmodium berghei sporozoites into Norway-Brown rats, we were able to localize these sporozoites and the early hepatic trophozoites developing from them in histological sections of the liver stained with a sensitive immunogold-silver procedure. Sporozoites invading hepatocytes released substantial quantities of circumsporozoite protein into the hepatocyte cytoplasm. This int...
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Circumsporozoite protein (CS) is a leading vaccine antigen for falciparum malaria, but is highly polymorphic in natural parasite populations. The factors driving this diversity are unclear, but non-random assortment of the T cell epitopes TH2 and TH3 has been observed in a Kenyan parasite population. The recent publication of the crystal structure of the variable C terminal region of the protei...
متن کاملgenetic diversity in the circumsporozoite protein gene of plasmodium falciparum from major endemic regions of iran
circumsporozoite protein (csp) is one of the stage specific antigens, which is used for the development of vaccines and to investigate the genetic diversity in plasmodium falciparum malaria parasite. polymerase chain reaction was used for typing of csp genes on 67 positive falciparum malaria patients from sistan and baluchistan province of iran. three fragments were detected for csp gene. twent...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1986
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.6.11.3965